Home > Health Library > Anticholinergics (Antispasmodics) for Irritable Bowel Syndrome
Antispasmodics relax the smooth muscles of
the gut, helping to prevent or relieve painful cramping spasms in the
intestines. These medicines can be taken as needed for cramps. They can also
be taken 30 to 45 minutes before meals that you expect might cause symptoms or
when symptoms would be inconvenient or bothersome.
Antispasmodics are used to relieve
cramps or spasms of the stomach, intestines, or bladder.
Some studies suggest that
antispasmodics improve symptoms of IBS and reduce pain. But studies on antispasmodics available in the United States
have been less promising. Some studies show a benefit, and some don't.1
Side effects may include drowsiness, dry
mouth, blurred vision, or an inability to urinate. Antispasmodics may make
constipation—often a main symptom of IBS—worse.
See Drug Reference
for a full list of side effects. (Drug Reference is not available in all
If constipation is your main
symptom, antispasmodics may not work for you. In some cases, use of
antispasmodics can make constipation worse.
If you are pregnant,
ask your doctor about taking antispasmodics. Some studies have suggested that
some antispasmodics can increase the heartbeat of a fetus, and that some are
related to birth defects, though they have not been proved to cause these
Complete the new medication information form (PDF)new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
American College of Gastroenterology (2009). An evidence-based systematic review on the
management of irritable bowel syndrome. American Journal of Gastroenterology, 104(Suppl 1): S8–S35.
April 26, 2012
E. Gregory Thompson, MD - Internal Medicine & Arvydas D. Vanagunas, MD - Gastroenterology
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