National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Anaphylaxis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • Allergic Reaction, Severe
  • Anaphylactic Reaction
  • Generalized Anaphylaxis

Disorder Subdivisions

  • None

General Discussion

Anaphylaxis is a rare, generalized, potentially life-threatening allergic reaction to a particular substance (allergen) to which individuals have previously developed an extreme sensitivity (hypersensitivity). The reaction typically occurs within seconds or minutes or, more rarely, up to a few hours after exposure to such an allergen. Allergens may include insect venom, certain foods, medications, vaccines, chemicals, or other substances. An anaphylactic reaction may be characterized by development of an itchy, reddish rash (hives); a severe drop in blood pressure; swelling and obstruction of the mouth, nose, and throat; abdominal cramps; nausea and vomiting; diarrhea; and severe difficulties breathing. Without immediate, appropriate treatment, the condition may rapidly lead to a state of unconsciousness (coma) and life-threatening complications.


Asthma and Allergy Foundation of America, Inc.
8201 Corporate Drive
Suite 1000
Landover, MD 20785
Tel: (202)466-7643
Tel: (800)727-8462

NIH/National Institute of Allergy and Infectious Diseases
NIAID Office of Communications and Government Relations
5601 Fishers Lane, MSC 9806
Bethesda, MD 20892-9806
Tel: (301)496-5717
Fax: (301)402-3573
Tel: (866)284-4107
TDD: (800)877-8339

American Academy of Allergy, Asthma and Immunology
611 East Wells Street
Milwaukee, WI 53202
Tel: (414)272-6071
Fax: (414)276-3349
Tel: (800)822-2762

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated:  4/4/2008
Copyright  1989, 2000, 2002, 2003 National Organization for Rare Disorders, Inc.