Fetal Valproate Syndrome

National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Fetal Valproate Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • Dalpro, Fetal Effects From
  • Depakene, Fetal Effects From
  • Depakote Sprinkle, Fetal Effects From
  • Depakote, Fetal Effects From
  • Divalproex, Fetal Effects From
  • Epival, Fetal Effects From
  • Myproic Acid, Fetal Effects From
  • Valproic Acid, Fetal Effects From
  • Fetal Anti-Convulsive Syndrome

Disorder Subdivisions

  • None

General Discussion

Fetal Valproate Syndrome is a rare congenital disorder caused by exposure of the fetus to valproic acid (dalpro, depakene, depakote, depakote sprinkle, divalproex, epival, myproic acid) during the first three months of pregnancy. Valproic acid is an anticonvulsant drug used to control certain types of seizures in the treatment of epilepsy. A small percentage of pregnant women who take this medication can have a child with Fetal Valproate Syndrome. The exact prevalence of this condition remains to be established. Symptoms of this disorder may include spina bifida, distinctive facial features, and other musculoskeletal abnormalities.


Spina Bifida Association of America
4590 MacArthur Boulevard NW
Suite 250
Washington, DC 20007-4226
Tel: (202)944-3285
Fax: (202)944-3295
Tel: (800)621-3141
Email: sbaa@sbaa.org
Internet: http://www.sbaa.org

International Federation for Spina Bifida and Hydrocephalus
Cellebroersstraat 16
Brussels, B1000
Tel: 32025020413
Fax: 32025021129
Email: info@ifglobal.org
Internet: http://www.ifglobal.org

Spina Bifida and Hydrocephalus Canada
Suite 647-167 av. Lombard Avenue
R3B 0V3
Tel: 2049253650
Fax: 2049253654
Tel: 8005659488
Email: info@sbhac.ca
Internet: http://www.sbhac.ca

Organisation For Anti-Convulsant Syndrome
23 Morriston Close
South Oxhey
Watford, WD196UB
United Kingdom
Tel: 4402083869271
Email: OACSsecretary@gmail.com
Internet: http://www.oacscharity.org

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  4/25/2008
Copyright  1994, 2003 National Organization for Rare Disorders, Inc.